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E.g., 29/03/2024
Cells use two mechanisms to detect force: one gradual and progressive mediated by newly identified large membrane depressions called dolines (left); the other abrupt, activated above a certain threshold, and mediated by minute membrane invaginations called caveolae (right).
Research
23 Dec 2022

A study published in Nature Cell Biology confirms that caveolae are essential for the mechanical responses of tissues subject to large mechanical forces (such as muscle, heart, blood vessels, and fat), whereas larger membrane depressions (termed 'dolines') are important for the response to weak or medium-strength forces

Fibroblasto embrionario murino Cav1KO (izquierda, sin caveolas) muestra un mayor reclutamiento de integrina beta 1 activa (magenta) en torno a bolitas recubiertas con fibronectina, en comparación con un fibroblasto embrionario murino Cav1WT (derecha, con caveolas).
Research
13 Dec 2022

A new study published in eLife shows that small cups or nanofolds on the cell membrane called caveolae, by limiting abrupt changes in membrane tension, regulate the number and activity of mechanical microsensors on the cell surface called integrins

About the CNIC
8 Jun 2021

Dr Enríquez and Dr del Pozo Muñoz join their colleagues Dr Miguel Torres, Dr Pura Muñoz and Dr Francisco Sánchez Madrid,  bringing to five the number of CNIC members in EMBO