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    E.g., 15/06/2025
    E.g., 15/06/2025
    Sarai Martínez Cano, Marcos Femenía Muiña, Elena Hernández, Vanessa Núñez, Manuel Rodrigo Tapias, Miguel Galán Burgos, Iñaki Robles, Alberto Benguria, David Sancho y Almudena Ramiro
    Research
    2 Jun 2025
    Circulation Research: CNIC scientists uncover how the immune response drives atherosclerosis—the root cause of heart attacks and strokes

    A team from the CNIC has discovered the key role of conventional type 1 dendritic cells (cDC1) in atherosclerosis and has developed an experimental therapy with immunosuppressive nanoparticles that slows the progression of the disease in animal models.
    Representative results from participants showing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image pair shows the results of the initial study at baseline and the follow-up study of the same artery 6 years later. The images show representative vascular ultrasound images on the right and 3-dimensional reconstructions on the left.
    Research
    20 Nov 2023
    JACC: Younger people are more vulnerable to the effects of cardiovascular risk associated with high blood cholesterol and hypertension

    Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough
    Research
    29 Jun 2021
    JACC: Spanish scientists provide the first demonstration that triglycerides are a primary risk factor in atherosclerosis

    A study published in JACC shows that excess circulating triglyceride concentrations are associated with subclinical atherosclerosis and vascular inflammation in individuals with low-to-moderate cardiovascular risk according to standard scores
    A cholesterol plaque in a carotid artery, visualized by vascular magnetic resonance imaging.
    Research
    12 Dec 2017
    'JACC': LDL cholesterol is the main modifiable predictor of atherosclerosis in individuals with no risk factors

    CNIC researchers have demonstrated that, after age and male sex, LDL-C is the main predictor of the presence of arterial atherosclerotic plaques