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    E.g., 17/09/2025
    E.g., 17/09/2025
    CNIC-led REBOOT clinical trial challenges 40-year-old standard of care for heart attack patients
    Research
    30 Aug 2025
    NEJM & The Lancet: CNIC-led REBOOT clinical trial challenges 40-year-old standard of care for heart attack patients

    REBOOT trial, coordinated by the CNIC, shows that treatment with beta-blockers provides no benefit to patients who experience an uncomplicated heart attack that leaves the contractile function of the heart intact.
    ESC Congress 2025
    About the CNIC
    30 Aug 2025
    EHJ: New study finds that, after a heart attack, women have worse prognosis when treated with beta-blockers

    The REBOOT study was presented during the European Society of Cardiology Congress (ESC Congress 2025) in Madrid
    Sarai Martínez Cano, Marcos Femenía Muiña, Elena Hernández, Vanessa Núñez, Manuel Rodrigo Tapias, Miguel Galán Burgos, Iñaki Robles, Alberto Benguria, David Sancho y Almudena Ramiro
    Research
    2 Jun 2025
    Circulation Research: CNIC scientists uncover how the immune response drives atherosclerosis—the root cause of heart attacks and strokes

    A team from the CNIC has discovered the key role of conventional type 1 dendritic cells (cDC1) in atherosclerosis and has developed an experimental therapy with immunosuppressive nanoparticles that slows the progression of the disease in animal models.
    Enrique Lara-Pezzi, Laura Lalaguna, Benedetta Coppe, Nadia Mercader y María Galardi-Castilla.
    Research
    2 Apr 2025
    Circulation: The heart remembers: scientists describe how early-life cardiac injury in parents influences the development and function of the heart in the next generation

    Scientists at the CNIC and the University of Bern have found that heart surgery in male mice early in life creates a "memory" passed down to the next generation. Published in Circulation, the study suggests that a parental history of heart surgery should be considered when evaluating cardiovascular health in descendants.
    About the CNIC
    18 Mar 2025
    CNIC joins GRACE, a European project aimed at transforming cardiovascular care through innovation and collaboration

    The CNIC has been allocated €405,625 for its involvement in GRACE, a project focused on developing innovative strategies to improve the detection and management of cardiovascular diseases.
    Dr. Fuster
    About the CNIC
    17 May 2024
    Dr Valentín Fuster receives the AstraZeneca Foundation Honorific Award for Excellence in Scientific Research
    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    Descubren un factor clave que protege el corazón tras un infarto
    About the CNIC
    2 Nov 2022
    JCI: CNIC scientists identify a factor that protects the heart against damage after a heart attack

    A new study defines a mechanism that regulates inflammation after a myocardial infarction, opening a path to the use of the receptor

    Fernando de Frutos y el Dr. Pablo García Pavía.
    Research
    29 Aug 2022
    JACC: CNIC scientists describe key features of one of the most frequent forms of hereditary dilated cardiomyopathy

    The findings, published in the Journal of the American College of Cardiology (JACC), represent a first step towards the personalized treatment of patients with this disease
    Valentín Fuster
    Research
    26 Aug 2022
    NEJM: The polypill reduces cardiovascular mortality by 33% in patients treated after myocardial infarction

    The results of the SECURE trial, coordinated by CNIC were presented in a Hot Line session at the European Society of Cardiology meeting (ESC 2022) in Barcelona and published at the NEJM