Selected publications

Martinez-Martinez S, Lozano-Vidal N, Lopez-Maderuelo MD, Jimenez-Borreguero LJ, Armesilla AL, Redondo JM. Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice. FEBS J (2019) 286:46-65
Villahoz S, Yunes-Leites PS, Mendez-Barbero N, Urso K, Bonzon-Kulichenko E, Ortega S, Nistal JF, Vazquez J, Offermanns S, Redondo JM*, Campanero MR*. (JMR and MRC are co-corresponding authors) Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. Nat Commun (2018) 9:4795
Link to the full text in Repisalud
Alfranca A*, Campanero MR, Redondo JM*. (AA and JMR are co-corresponding authors) New Methods for Disease Modeling Using Lentiviral Vectors. Trends Mol Med (2018) 24:825-37
de Carcer G, Wachowicz P, Martinez-Martinez S, Oller J, Mendez-Barbero N, Escobar B, Gonzalez-Loyola A, Takaki T, El Bakkali A, Camara JA, Jimenez-Borreguero LJ, Bustelo XR, Canamero M, Mulero F, de los Angeles Sevilla M, Montero MJ, Redondo JM*, Malumbres M*. (JMR and MM are co-corresponding authors) Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat Med (2017) 23:964-74
Oller J*, Mendez-Barbero E*, Ruiz EJ, Villahoz S, Renard M, Canelas LI, Briones AM, Alberca R, Lozano-Vidal N, Hurle MA, Milewicz D, Evangelista A, Salaices M, Nistal JF, Jimenez-Borreguero LJ, De Backer J, Campanero MR*, Redondo JM*. (JO and NMB contributed equally, MRC and JMR are co-corresponding authors) Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome Nat Med (2017) 23:200-12
Link to the full text in Repisalud
Gómez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acín-Pérez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jiménez-Alcázar M, Segalés J, López-Maderuelo D, Ornés B, Jiménez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Muñoz-Cánoves P, Redondo JM The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis Cell Metab (2016) 23:881-92
Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Nat Commun (2016) 7:10477
Link to the full text in Repisalud
Oller J*, Alfranca A*, Mendez-Barbero N, Villahoz S, Lozano-Vidal N, Martin-Alonso M, Arroyo AG, Escolano A, Armesilla AL, Campanero MR, Redondo JM (JO and AA contributed equally) C/EBPbeta and NFAT differentially regulate Adamts-1 induction by stimuli associated with vascular remodeling. Mol Cell Biol (2015) 35:3409-22
Escolano A, Martinez-Martinez S, Alfranca A, Urso K, Izquierdo HM, Delgado M, Martin F, Sabio G, Sancho D, Gomez-Del Arco P and Redondo JM. Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38. EMBO J (2014) 33:1117-33
Baggott RR, Alfranca A, Lopez-Maderuelo D, Mohamed TM, Escolano A, Oller J, Ornes BC, Kurusamy S, Rowther FB, Brown JE, Oceandy D, Cartwright EJ, Wang W, Gomez-Del Arco P, Martinez-Martinez S, Neyses L, Redondo JM*, Armesilla AL* (JMR and ALA are co-corresponding authors) Plasma Membrane Calcium ATPase Isoform 4 Inhibits Vascular Endothelial Growth Factor-Mediated Angiogenesis Through Interaction With Calcineurin Arterioscler Thromb Vasc Biol (2014) 34:2310-20
Sanchez SA*, Mendez-Barbero N*, Santos-Beneit AM, Esteban V, Jimenez-Borreguero LJ, Campanero MR* and Redondo JM* (SAS and NMB contributed equally; MRC and JMR are co-corresponding authors) Nonlinear optical 3-dimensional method for quantifying atherosclerosis burden. Circ Cardiovasc Imaging (2014) 7:566-9
Méndez-Barbero N*, Esteban V*, Villahoz S, Escolano A, Urso K, Alfranca A, Rodríguez C, Sánchez SA, Osawa T, Andrés V, Martínez-González J, Minami T, Redondo JM, Campanero MR (NMB and VE contributed equally; JMR and MRC are co-corresponding authors) A major role for RCAN1 in atherosclerosis progression. EMBO Mol Med (2013) 5:1901-17
Link to the full text in Repisalud
Salvado MD, Alfranca A, Haeggström JZ, Redondo JM. Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2. Trends Mol Med (2012) 18:233-43
Esteban V*, Mendez-Barbero N*, Jimenez-Borreguero JL, Roque M, Novensa L, Garcia-Redondo AB, Salaices M, Vila L, Albonés ML, Campanero MR* and Redondo JM* (VE and NMB contributed equally; MRC and JMR are co-corresponding authors) Regulator of calcineurin 1 mediates pathological vascular wall remodeling J Exp Med (2011) 208:2125-39
Urso K, Alfranca A, Marti­nez-Martinez S, Escolano A, Ortega I, Rodriguez A*, Redondo JM* (AR and JMR are co-corresponding authors) NFATc3 regulates the transcription of genes involved in T cell activation and angiogenesis. Blood (2011) 118:795-803
Gómez-Del Arco P, Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K. Alternative promoter usage at the notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity (2010) 33:685-98
Rodriguez A, Roy J, Martinez-Martinez S, Lopez-Maderuelo MD, Nino-Moreno P, Orti L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants Mol Cell (2009) 33:616-26
Martinez-Martinez S, Genescà L, Rodriguez A, Raya A, Salichs E, Were F, Lopez-Maderuelo MD, Redondo JM*, de la Luna S* (JMR and SDLL are co-corresponding authors) The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators. Proc Natl Acad Sci U S A (2009) 14:6117-22
Salvado MD, Alfranca A, Escolano A, Haeggström JZ, Redondo JM. COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH2 for Transcellular Metabolism to PGE2 by Tumor Cells. Arterioscler Thromb Vasc Biol (2009) 29:1131-7
Alfranca A, López-Oliva JM, Genís L, López-Maderuelo D, Mirones I, Salvado D, Quesada AJ, Arroyo AG, Redondo JM. PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway. Blood (2008) 112:1120-8