Antibodies for the diagnosis and/or treatment of atherosclerosis
Novel atherosclerosis biomarkers are in need to improve the strategies for diagnosis and prognosis of cardiovascular disease. CNIC and DKFZ researchers have discovered 18 novel antibodies that show reactivity against the atherosclerotic plaque, which can thus be potentially used for the diagnosis of this disease. Moreover, the use of one such antibody, A12, delays the progression of atherosclerosis and reduces the level of free circulating cholesterol and LDL.
Scientific article: https://doi.org/10.1038/s41586-020-2993-2NumberEP20786476Priority date23/09/2019ApplicantsCNIC, DKFZInventorsAlmudena Rodríguez Ramiro, Cristina Lorenzo Martín, Hedda Wardemann, Christian Busse