Compounds with anti-inflammatory properties
Researchers at the UV, together with research staff from CSIC, the UCM and the CNIC, as well as researcher Jesús del Pozo, have produced several compounds through the chemical synthesis process and the production of imidazo[1,2-a]pyridine derivatives with powerful anti-inflammatory properties in vitro and in vivo in diseases involving inflammatory and pro-fibrotic processes. The imidazo[1,2-a]pyridine backbone is present in many commercial drugs, showing many therapeutic applications. The compounds in this invention are based on structures with Alk5 tyrosine kinase inhibitor activity, which is the receptor I of transforming growth factor TGFβ. These compounds demonstrate powerful anti-inflammatory properties both in vitro (on cultured human macrophages) and in vivo on an animal model, as well as anti-fibrotic effect in a murine model.
More information: https://www.uv.es/scientific-technological-offer/en/results/health/non-communicable-rare-diseases/chemical-synthesis-imidazo-1-2-a-pyridine-derivatives-anti-inflammatory-properties-1286222426833/OCTResultats.html?id=1286336417157NumberP202330530Priority date27/06/2023ApplicantsUV, CNIC, CSIC, UCM, Jesús del PozoInventorsJesús del Pozo Losada, Carlos del Pozo Losada, Christian Miquel Sánchez López, Francisco Antonio Sánchez Sancho, Aurelio García Csaáky, Eduardo Oliver Pérez, Borja Ibáñez Cabeza, María Gracia Baquero Gálvez, Silvia Roscales García, Jose María Cumella Mont