News search

    E.g., 02/06/2025
    E.g., 02/06/2025
    David Sancho, Ignacio Heras-Murillo y Stefanie Wculek.
    Research
    14 Apr 2025
    Nature Communications: A type of immune cell strengthens immunotherapy and prevents tumor relapse in animal models

    A study led by the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), in collaboration with the Instituto de Investigación Biomédica de Barcelona (IRB Barcelona), has identified the most effective subtype of dendritic cell for generating immune memory in response to cancer
    Juan Pablo Ochoa, Pablo García-Pavía, Laura Lalaguna, Marina López-Olañeta, María Arévalo-Núñez de Arenas y Enrique Lara-Pezzi.
    Research
    9 Apr 2025
    Circulation Research: Breakthrough gene therapy offers hope for rare, deadly heart disease in young men

    A CNIC team has developed an innovative gene therapy strategy for arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5), a rare and deadly inherited condition that particularly affects young men
    Gabriel Núñez
    About the CNIC
    8 Apr 2025
    Gabriel Núñez: "There is no unique, perfect microbiota"
    Anagha Jagannathan, Carlos Real Jiménez, Laura Cádiz, Sofía Trigo Anca, Anabel Díaz-Guerra Priego, Miguel Fernández Tocino, Carlos Galán Arriola, Borja Ibáñez, Agustín Clemente Moragón, Sandra Gomez, Ana Devesa, Juan Rene Delgado Cornejo, Danielle Medina-Hernandez, Warren Alexander Skoza, Lucía Pilar López Palomar, Nico Hoffmann, Carlos Caballero Henares and Ángela Pollán García.
    Research
    4 Feb 2025
    JACC CardioOncology: CNIC scientists design an effective treatment strategy to prevent heart injury caused by a class of anticancer drugs

    The study, published in JACC: CardioOncology, shows that administration of the SGLT2 inhibitor empagliflozin to pigs receiving anthracyclines preserves mitochondrial function, improves myocardial energetics, and prevents degenerative changes in heart structure
    imagen
    About the CNIC
    30 Sep 2024
    CNIC Joins the 2024 Heart Race
    Cardiovascular risk factors (particularly metabolic syndrome, insulin resistance, and diabetes) alter coronary microvascular function and increase the risk of atherosclerotic disease, which itself leads to changes in the coronary microcirculation.
    Research
    19 Sep 2024
    JACC: Cardiovascular Imaging: Cardiometabolic risk factors in apparently healthy individuals are linked to altered coronary microcirculation

    A study from CNIC reveals how risk factors and subclinical atherosclerosis affect heart microcirculation in asymptomatic middle-aged individuals. The research, published in JACC: Cardiovascular Imaging, highlights the importance of assessing the heart vessels' ability to regulate blood flow and predict future cardiovascular risk
    CNIC researchers
    Research
    30 Aug 2024
    Nature Medicine: CNIC scientists discover a new cardiovascular risk factor and identify a drug able to reduce its effects

    Two studies carried out at the CNIC provide key information about a newly identified cardiovascular risk factor, clonal hematopoiesis, and its treatment with the ancient medication colchicine
    Carlos Torroja, Jacob F. Bentzon, Paula Nogales, Laura Carramolino, Vanessa Cumbicus, Daniel Morales, Ana Dopazo, Verónica Labrador y Alberto Benguria
    Research
    1 Feb 2024
    Nature Cardiovascular Research: New approach to the design of therapies that enhance the effect of cholesterol-lowering drugs

    A study published in Nature Cardiovascular Research reveals smooth muscle-derived cells as a new target for reducing the size of atherosclerotic plaque. The results open up new avenues for the design of treatments to enhance the beneficial effect of cholesterol-lowering drugs
    Representative results from participants showing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image pair shows the results of the initial study at baseline and the follow-up study of the same artery 6 years later. The images show representative vascular ultrasound images on the right and 3-dimensional reconstructions on the left.
    Research
    20 Nov 2023
    JACC: Younger people are more vulnerable to the effects of cardiovascular risk associated with high blood cholesterol and hypertension

    Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough
    De izquierda a derecha: Cristina Sanchez-Ramos, Nieves Garcia-Quintans, David Morera, Mariya Lytvyn, Juan A Bernal, Mª Ángeles Sanguino, Daniel Martín Perez, Fernando de Benito, David Sanz y Emilio Camafeita
    Research
    23 Oct 2023
    Nature Communications: Spanish scientists discover a possible treatment for a heart condition that causes an estimated 20% of sudden deaths among athletes

    This disease, which can trigger sudden death in elite athletes, is caused by genetic mutations that affect proteins responsible for connecting and coordinating the muscle cells (myocytes) in the myocardium the heart’s muscular wall