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E.g., 28/06/2024
About the CNIC
15 May 2024

Globally, cardiovascular diseases due to atherosclerosis – the build-up of plaque in arteries – are the leading cause of death. A new Danish-Spanish research collaboration aims to develop methods to detect atherosclerosis at earlier ages and encourage prevention. Denmark’s Novo Nordisk Foundation has granted up to EUR 23 million to cover the first 2.5 years of the REACT initiative. The initiative is expected to run for 8 years in total


Catarina Tristão Pereira, Enrique Lara Pezzi, Raquel Toribio Fernández, Borja Ibáñez, Valentín Fuster, Sergio Callejas, Marta Cortés Canteli, Ana Dopazo, Pilar Martín, Inés García Lunar e Irene Fernández Nueda.
Research
23 Jan 2024

The most potent genetic risk factor for Alzheimer disease, APOE4, is associated with an elevated risk of developing subclinical atherosclerosis in middle age, whereas the Alzheimer-protective variant of the same gene, APOE2, protects against subclinical atherosclerosis

David Sancho
About the CNIC
19 Jan 2024

The ImnovAth project seeks an innovative approach to treat atherosclerosis

Representative results from participants showing atherosclerosis progression (left) and regression (disappearance of plaques, right) in arteries of the neck (carotids) and groin (femorals). Each image pair shows the results of the initial study at baseline and the follow-up study of the same artery 6 years later. The images show representative vascular ultrasound images on the right and 3-dimensional reconstructions on the left.
Research
20 Nov 2023

Atherosclerosis, previously believed to be an irreversible progressive disease, can be reversed if risk factors are contolled early enough

De izda. a dcha.: Gema González, Estefanía Núñez, Sergio Callejas, Juan Carlos Silla, Enrique Lara-Pezzi, Valentín Fuster, Fátima Sánchez Cabo, José Javier Fuster, Ana Dopazo, Borja Ibáñez, Marta Cortés, Alberto Benguría y Antonio Quesada.
Research
21 Jun 2023

A new CNIC study shows that low-grade systemic inflammation triggered by subcinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals

Enrique Calvo, Jesús Vázquez, Álvaro Alfayate, Estefanía Núñez y José Luis Martín Ventura.
Research
28 Mar 2022

A study published in the journal eBiomedicine identifies new biomarkers that predict the presence of subclinical atherosclerosis

Research
29 Jun 2021

A study published in JACC shows that excess circulating triglyceride concentrations are associated with subclinical atherosclerosis and vascular inflammation in individuals with low-to-moderate cardiovascular risk according to standard scores

Almudena Ramiro
About the CNIC
15 Jun 2021

The team led by Dr Ramiro has identified a target protein for the diagnosis and treatment of vascular pathologies


Jesús Vázquez, Jacob Fog Bentzon, Emilio Camafeita y Esmeralda Lewis.
About the CNIC
13 Apr 2021

The new insight supports the need to keep both LDL cholesterol and blood pressure low throughout life by healthy diet choices, weight control, exercise, and, when needed, by drug therapy

3D reconstructions of superior (left) and inferior (right) brain regions, showing regions with lower metabolism associated with the presence of atherosclerotic plaques in the carotid arteries. The color code indicates the magnitude of the observation (yellow, strong association; red, lower association). Gray indicates areas showing no association with carotid plaque presence
Research
15 Feb 2021

Among the modifiable cardiovascular risk factors showing a close association with reduced brain metabolism, the research team found that the most important is hypertension