News search

E.g., 25/04/2024
E.g., 25/04/2024
RM cardiaca de un paciente con miocardiopatía dilatada (izquierda) y de un individuo sin cardiopatía (derecha). En el paciente con miocardiopatía dilatada el tamaño del corazón esta incrementado y su capacidad de bombeo está disminuida.
Research
19 Apr 2024

The results, published in JACC, suggest that these factors could be used to predict the risk of developing dilated cardiomyopathy and adapt strategies for patient care and disease detection in genetic carriers of the disease

Dr. García Pavía
Research
21 May 2023

The team led by Dr. Pablo García-Pavía, based at the CNIC and Hospital Puerta de Hierro, has published the first study of a drug able to remove amyloid deposits from the heart

Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Giovanna Giovinazzo, Fátima Sánchez-Cabo, Belén Prados, José Luis de la Pompa, Marcos Siguero-Álvarez, Sergio Callejas, Carlos Torroja, Ana Dopazo, Jorge de la Barrera, Donal MacGrogan y Manuel José Gómez.
Research
7 Nov 2022

A CNIC study reveals that mutations previously identified in the gene MINDBOMB1 (MIB1) as causing non-compaction cardiomyopathy either provoke this disease or valve defects, depending on their combination with mutations in modifier genes

Pablo García Pavía and Luis Escobar
Research
12 Sep 2022

The findings, published in the Journal of the American College of Cardiology (JACC), will enable physicians to make appropriate treatment adjustments for patients with this disease


Fernando de Frutos y el Dr. Pablo García Pavía.
Research
29 Aug 2022

The findings, published in the Journal of the American College of Cardiology (JACC), represent a first step towards the personalized treatment of patients with this disease

Imagen de histología que muestra la comparación del tamaño del corazón de un ratón normal (izquierda) y un ratón deficiente para la proteína MKK6 (derecha).
Research
9 Aug 2022

A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members

Dr. Pablo García-Pavía y Dr. Jesús Gonzalez Mirelis, codirectores del trabajo.
Research
22 Jul 2022

Genetic screening combined with the detection of fibrosis identifies patients at risk of malignant arrhythmias or developing heart failure with severe complications


Scheme of a cMyBP-C region in which mutations cause amino-acid changes that alter the mechanical properties of the protein. The positions of the affected amino acids are shown in red.
Research
7 Jun 2021

A team led by Dr. Jorge Alegre-Cebollada has shown, for the first time, an association between hypertrophic cardiomyopathy and mechanical alterations to a component of the contractile machinery of the heart

From left to right: Marta Román, Fernando Domínguez, Laura Padrón-Barthe, Pablo Garcia-Pavia, Giovanna Giovinazzo, Enrique Lara-Pezzi, Demetrio J. Santiago, Javier Larrasa-Alonso
Research
5 Sep 2019

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Puerta de Hierro hospital in Majadahonda have found a possible treatment for this disease

Research
3 Dec 2015

A defect in mitochondria in the heart causes dilated cardiomyopathy, leading to heart disease and early death