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    E.g., 22/09/2023
    E.g., 22/09/2023
    Dr. García Pavía
    Research
    21 May 2023
    NEJM: A Spanish team presents the first pharmacological treatment able to improve cardiac function in stiff-heart syndrome

    The team led by Dr. Pablo García-Pavía, based at the CNIC and Hospital Puerta de Hierro, has published the first study of a drug able to remove amyloid deposits from the heart

    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research
    29 Nov 2022
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart
    Imagen de histología que muestra la comparación del tamaño del corazón de un ratón normal (izquierda) y un ratón deficiente para la proteína MKK6 (derecha).
    Research
    9 Aug 2022
    eLife: CNIC scientists uncover opposing roles of p38 proteins in cardiac hypertrophy

    A new study published in eLife shows that inhibition of p38γ/δ is a potential therapeutic strategy for the treatment of hypertrophic cardiomyopathy, but that this strategy has yet to be explored because of the lack of specific inhibitors for these p38 family members
    An optical section from a ventral view of a mouse embryo at embryonic day E8.0. The section is overlain with a cast of the three-dimensional shape of the forming heart (red) and the incipient circulatory system (purple).
    Research
    17 May 2022
    Nature Cardiovascular Research: A CNIC team creates a dynamic 3D atlas of the formation of the embryonic heart

    The 3D atlas has allowed the scientists to identify the beginning of left–right asymmetry in the heart
    De izquierda a derecha: Enrique Lara-Pezzi, Laura Lalaguna, Laura Ramos, Elena González, María Villalba, Claudia Camarero, Marina López, Betel Olaizola, Ascensión Rey, Carlos Martí, Elísabet Bello y Javier Larrasa
    Research
    3 Sep 2021
    Circulation Research: CNIC scientists describe one of the mechanisms underlying cardiac hypertrophy

    The new findings, published in Circulation Research, could spur the development of new tools for the treatment of cardiac hypertrophy
    Mª Ángeles Zuriaga, Mirian Díez, Fátima Sánchez-Cabo, Ana Dopazo, José Javier Fuster, Ana Quintas y Jorge de la Barrera.
    Research
    5 Apr 2021
    JACC: CNIC scientists identify mutations acquired by blood cells that accelerate heart failure progression

    The study, carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Hospital Universitario Virgen de Arrixaca in Murcia, establishes clonal hematopoiesis as a new cardiovascular risk factor and an important link between aging and cardiovascular disease
    Research
    29 May 2020
    Alejandro Sánchez Alvarado: "The real magic is to imagine the experiment and execute it"

    The researcher Alejandro Sánchez Alvarado is one of the greatest experts in the study of the mechanisms involved, cellular and biological, in regeneration in the planaria model
    Research
    31 Oct 2019
    REANIMA: toward a new paradigm in cardiac regeneration

    Dr. Miguel Torres, of the Centro Nacional de Investigaciones Cardiovasculares (CNIC), leads a new project that will receive €8 million in funding over 5 years, €1,380,000 of which will be directly managed at the CNIC
    De izda. a dcha.: José Antonio Enriquez, María del Mar Muñoz, Fátima Sánchez-Cabo, Luis Jesús Jiménez-Borreguero, Rocío Nieto-Arellano, Andrés González-Guerra, Carlos Torroja, José María Castellanos, y Concepción Jiménez.
    Research
    3 Apr 2018
    Science Translational Medicine: CNIC scientists identify a promising target for the treatment of heart failure

    The study is published in Science Translational Medicine and was conducted by researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
    Jesús Vázquez, María Villalba, Sara Cogliati, Marina López, Paula Ortiz, José Antonio Enriquez, Laura Padrón, Elena Bonzón y Enrique Lara.
    Research
    6 Feb 2018
    JACC: An enzyme variant reduces cardiac hypertrophy and improves heart function

    The calcineurin variant CnAβ1 redirects glucose metabolism to increase production of antioxidant compounds, reducing cardiac hypertrophy and improving heart function