About the CNIC, Research
    Dr. Francisco Sánchez-Madrid awarded the 2023 Robert Koch Prize

    This work is of fundamental importance for understanding the immune system and its reactions

    Neuregulin-1 induces changes in actin filaments during ventricular maturation. Actinin staining of a mouse embryo heart reveals a striated actin pattern corresponding to mature trabecular sarcomeres (green). The magnified view shows the differences in luminosity that distinguish the more organized actin filaments of the trabecular myocardium from the less organized compact layer
    Research, Publications
    CIRCULATION RESEARCH: CNIC scientists identify the crucial role of the protein neuregulin-1 in heart development

    Neuregulin-1 (Nrg1) plays an essential role in the transformation of the heart from its delicate primordial structure into the powerful beating mature organ 

    Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Donald McGrogan y José Luis de la Pompa.
    Research, Publications
    Jama Cardiology: An international team identifies the mutations that cause the most frequent congenital heart defects

    A multicenter study published in JAMA Cardiology and co-led by scientists at Hadassah Medical Center, Sheba Medical Center, and the CNIC could help in the design of future pharmacological treatments for bicuspid aortic valve

    Transverse heart sections from wild type mice (WT) and transgenic mice overexpressing beta-3 adrenergic receptor in cardiomyocytes (c-h3tg) after 3 months of aortic stenosis (transaortic constriction, TAC) or control (sham). Hypertrophy after TAC was less severe in the transgenic mice
    Research, Publications
    Basic Research in Cardiology: A new therapeutic target for the prevention of heart failure due to aortic stenosis

    The experimental study, led by researchers at the CNIC, shows that boosting the expression of this adrenalin receptor in heart cells improves mitochondrial function in the heart

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