Jorge Nicolás Domínguez, Susana Temiño, Morena Raiola, Miquel Sendra y Miguel Torres.
    Research, Publications
    Developmental Cell: CNIC team reveals how the heart is organized from the earliest stages of embryonic development

    CNIC researchers have discovered that the heart is formed from two independent cell types that act in synchrony from the onset of gastrulation. This finding could help to better understand the origin of certain congenital heart defects and open up new opportunities in regenerative medicine and tissue bioengineering.

    Miembros del equipo del Dr. Miguel Torres.
    About the CNIC, Research, Publications
    The REACTIVA project, led by CNIC scientist Dr. Miguel Torres, receives ERC Advanced Grant funding

    The CNIC project will use innovative approaches to investigate cardiac regeneration

    An optical section from a ventral view of a mouse embryo at embryonic day E8.0. The section is overlain with a cast of the three-dimensional shape of the forming heart (red) and the incipient circulatory system (purple).
    Research, Publications
    Nature Cardiovascular Research: A CNIC team creates a dynamic 3D atlas of the formation of the embryonic heart

    The 3D atlas has allowed the scientists to identify the beginning of left–right asymmetry in the heart

    Skeletal staining of the inferior limb regions of normal embryos, embryos with a single Meis allele, and an embryo with complete absence of Meis. Embryos with a single copy of Meis lack the fibula and posterior digits (black arrow). Total absence of Meis prevents limb development (white arrow).
    Research, Publications
    Nature Communications: CNIC scientists identify essential factors for limb formation

    The study, published in Nature Communications, reveals that Meis transcription factors are essential for the formation and antero-posterior patterning of the limbs during embryonic development 

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