Selected publications

Tsilingiri K, de la Fuente H, Relano M, Sanchez-Diaz R, Rodriguez C, Crespo J, Sanchez-Cabo F, Dopazo A, Alonso-Lebrero JL, Vara A, Vazquez J, Casasnovas JM, Alfonso F, Ibanez B, Fuster V, Martinez-Gonzalez J, Martin P*, Sanchez-Madrid F*. (PM and FSM are co-corresponding authors) oxLDL Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease. Circulation (2019) 139:243-55
Link to the full text in Repisalud
Cortes-Canteli M, Kruyer A, Fernandez-Nueda I, Marcos-Diaz A, Ceron C, Richards AT, Jno-Charles OC, Rodriguez I, Callejas S, Norris EH, Sanchez-Gonzalez J, Ruiz-Cabello J, Ibanez B, Strickland S, Fuster V Long-Term Dabigatran Treatment Delays Alzheimer's Disease Pathogenesis in the TgCRND8 Mouse Model J Am Coll Cardiol (2019) 74:1910-23
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Zagorac I, Fernandez-Gaitero S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, Munoz J, Gomez-Lopez G, Lopez-Acosta JF, Jimenez-Renard V, Gris-Oliver A, Al-Shahrour F, Pineiro-Yanez E, Montoya-Suarez JL, Apala JV, Moreno-Torres A, Colomer R, Dopazo A, Heck AJR, Altelaar M, Quintela-Fandino M. In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer. Nat Commun (2018) 9:3501
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Alvarez-Prado AF, Perez-Duran P, Perez-Garcia A, Benguria A, Torroja C, de Yebenes VG, Ramiro AR. A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets. J Exp Med (2018) 215:761-771
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De Andres C, Garcia MI, Goicoechea H, Martinez-Gines ML, Garcia-Dominguez JM, Martin ML, Romero-Delgado F, Benguria A, Sanjurjo M, Lopez-Fernandez LA. Genes differentially expressed by methylprednisolone in vivo in CD4 T lymphocytes from multiple sclerosis patients: potential biomarkers. Pharmacogenomics J (2018) 18:98-105
Hill R, Madureira PA, Ferreira B, Baptista I, Machado S, Colaco L, Dos Santos M, Liu N, Dopazo A, Ugurel S, Adrienn A, Kiss-Toth E, Isbilen M, Gure AO, Link W. TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT. Nat Commun (2017) 8:14687
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Talayero P, Alonso-Guirado L, Padilla G, Artaza H, Dopazo A, Sanchez-Cabo F, Rodriguez-Munoz S, Calvo-Pulido J, Mancebo E, de Lacoba MG, Paz-Artal E. 5-gene differential expression predicts stability of human intestinal allografts. Exp Mol Pathol (2017) 103:136-71
Municio C, Soler Palacios B, Estrada-Capetillo L, Benguria A, Dopazo A, Garcia-Lorenzo E, Fernandez-Arroyo S, Joven J, Miranda-Carus ME, Gonzalez-Alvaro I, Puig-Kroger A. Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis. Ann Rheum Dis (2016) 75:2157-65
Blanco FJ, Ojeda-Fernandez L, Aristorena M, Gallardo-Vara E, Benguria A, Dopazo A, Langa C, Botella LM, Bernabeu C Genome-wide transcriptional and functional analysis of endoglin isoforms in the human promonocytic cell line U937 J Cell Physiol (2015) 230:947-58
Hill R, Kalathur R, Callejas S, Colaco L, Brandao R, Serelde B, Cebria A, Blanco-Aparicio C, Pastor J, Futschik M, Dopazo A, Link W A novel Phosphatidylinositol 3-Kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes Breast Cancer Res (2014) 16:482
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Aguilera-Montilla N, Chamorro S, Nieto C, Sánchez-Cabo F, Dopazo A, Fernández-Salguero PM, Rodríguez-Fernández JL, Pello OM, Andrés V, Cuenda A, Alonso B, Domínguez-Soto A, Sánchez-Ramón S, Corbi AL. Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells. Blood (2013) 121:e108-17
Trigueros-Motos L, González-Granado JM, Cheung C, Fernández P, Sánchez-Cabo F, Dopazo A, Sinha S, Andrés V. Embryological-Origin-Dependent Differences in Hox Expression in Adult Aorta: Role in Regional Phenotypic Variability and Regulation of NF-κB Activity. Arterioscler Thromb Vasc Biol (2013) 33:1248-56
Link to the full text in Repisalud
Estrada JC, Torres Y, Benguría A, Dopazo A, Roche E, Carrera-Quintanar L, Pérez RA, Enríquez JA, Torres R, Ramírez JC, Samper E*, Bernad A* (ES and AB contributed equally) Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy. Cell Death Dis (2013) 4:e691
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Estrada JC, Albo C, Benguría A, Dopazo A, López-Romero P, Carrera-Quintanar L, Roche E, Clemente EP, Enríquez JA, Bernad A*, Samper E* (AB and ES contributed equally) Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis. Cell Death Differ (2012) 19:743-55
Tomé M, López-Romero P, Albo C, Sepúlveda JC, Fernández-Gutiérrez B, Dopazo A, Bernad A*, González MA* (AB and MAG contributed equally) miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells. Cell Death Differ (2011) 18:985-95
Sánchez-Ramos C, Tierrez A, Fabregat-Andrés O, Wild B, Sánchez-Cabo F, Arduini A, Dopazo A, Monsalve M. PGC-1[alpha] regulates translocated in liposarcoma activity: role in oxidative stress gene expression. Antiox Redox Sign (2011) 12:325-37
Martín Y, Dopazo A, Hernández-Chico C. Progress and challenges in developing a molecular diagnostic test for neurofibromatosis type 1. Expert Rev Mol Diagn (2011) 11:671-3
Callejas S*, Alvarez R*, Dopazo A (SC and RA contributed equally) Automatic Genomics: a user-friendly program for the automatic designing and plate loading of medium-throughput qPCR experiments. Biotechniques (2011) 50:46-50