We are a multidisciplinary team of scientists who investigate how mechanical forces determine muscle function at the molecular, cellular, tissue and organismal levels. Our motivation is to improve the understanding, diagnosis and treatment of cardiovascular and musculoskeletal diseases. At the same time, we train scientists, awake vocations in science and contribute to strengthen and disseminate the scientific culture.
In the “Know more” page you will find more information about our current projects. Click on the “Interesting info” and “Downloads” sections for interesting links and files of the methods we use, lectures, seminars and talks. For updates and news, follow Jorge in twitter @AlegreCebollada.
 | News:- June 2025: We publish in Nature Biomedical Engineering our mechanical knock-out strategy to study proteins that work under force. When applied to titin, we show that appropriate tension across titin is needed to avoid muscle disease.
- November 2024. Our work on how cells sense and respond to the viscoelastic properties of the extracellular matrix is published in Science Advances.
- September 2024. Roberto and Miguel receive at the 51st European Muscle Conference in Ljubljana the first prizes of the Marcus Schaub Young Investigator Awards in the categories of best Oral Presentation and best Poster Presentation, respectively.
- August 2024. Roberto secures a Trampoline Research Grant from the French Muscular Distrophy Association, AFM-Téléthon.
- December 2023. We have published our work showing that missense variants altering the stability of titin domains can cause dilated cardiomyopathy in Cell Reports.
- September 2022. Miguel and Roberto are awarded a Juan De La Cierva contract and an EMBO Postdoctoral Fellowship, respectively. Congratulations!
- April 2022. We have published our observation that titin oxidation occurs in basal conditions in human and mice, modulating its mechanical properties.
- June 2021. Jorge is appointed to the Spanish Young Academy.
- December 2020. Our project ProtMechanics-Live has been awarded an ERC-consolidator grant. Many thanks to the many people that are contributing to our quest to understand the role of protein mechanics in vivo!
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