We are a multidisciplinary team of scientists who investigate how mechanical forces determine muscle function at the molecular, cellular, tissue and organismal levels. Our motivation is to improve the understanding, diagnosis and treatment of cardiovascular and musculoskeletal diseases. At the same time, we train scientists, awake vocations in science and contribute to strengthen and disseminate the scientific culture.
In the “Know more” page you will find more information about our current projects. Click on the “Interesting info” and “Downloads” sections for interesting links and files of the methods we use, lectures, seminars and talks. For updates and news, follow Jorge in twitter @AlegreCebollada.
 | News:- September 2025. Jorge receives the 2026 Michael and Kate Bárány Award from the Biophysical Society “for pioneering the study of protein mechanics in living systems”
- September 2025. Laura Sen receives a prize for best poster presentation at the 52nd European Muscle Conference in Amsterdam
- June 2025: We publish in Nature Biomedical Engineering our mechanical knock-out strategy to study proteins that work under force. When applied to titin, we show that appropriate tension across titin is needed to avoid muscle disease.
- November 2024. Our work on how cells sense and respond to the viscoelastic properties of the extracellular matrix is published in Science Advances.
- August 2024. Roberto secures a Trampoline Research Grant from the French Muscular Distrophy Association, AFM-Téléthon.
- December 2023. We have published our work showing that missense variants altering the stability of titin domains can cause dilated cardiomyopathy in Cell Reports.
- April 2022. We have published our observation that titin oxidation occurs in basal conditions in human and mice, modulating its mechanical properties.
- June 2021. Jorge is appointed to the Spanish Young Academy.
- December 2020. Our project ProtMechanics-Live has been awarded an ERC-consolidator grant. Many thanks to the many people that are contributing to our quest to understand the role of protein mechanics in vivo!
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